Postdoctoral Research Associate, Cancer Center (Full Time) (Multiple) The Theodorescu Lab within the University of Arizona Cancer Center (UACC) is looking to hire a postdoctoral researcher with a strong background in cancer immunology and the tumor microenvironment (TME). This project will characterize the tumor microenvironment of bladder cancer, focusing on mechanisms of immune evasion orchestrated by tumor cells while identifying immune system agonists or antagonists that modulate tumor behavior in vivo. To dissect cancer‑specific vulnerabilities, we will combine techniques of biochemistry, molecular biology, and CRISPR/Cas9 technologies, functional genomic approaches (loss of function/synthetic lethal), next‑generation sequencing including single‑cell RNA sequencing, together with innovative mouse models we have developed. Examples of the type of work undertaken can be seen in our papers by Abdel‑Hafiz (Nature. 2023 Jul;619(7970):624-631), Gouin (Nature Commun. 2021; 12;12(1)), Agarwal (Proc Natl Acad Sci U S A. 2021 Sep 21;118(38):e2102423118) and Tu (Science Adv. 2019; 20;5(2)). Our final goal is to identify novel biomarkers and interventions for cancer that will improve patient outcomes. The successful candidate will be a driven, creative, team‑oriented individual with a passion for discovering fundamental cancer biology mechanisms that have potential clinical impact and can be moved towards a clinical setting. We employ many different in‑vitro and in‑vivo approaches and seek individuals with a strong background in cell and molecular immunology. Duties & Responsibilities Design and perform experiments; keep detailed experimental records and documentation and analyze results with the Principal Investigator (PI). Develop, adapt, and implement new research techniques and protocols. Analyze, interpret, summarize, and compile data. Perform routine and complex laboratory procedures throughout the training period. Assist in preparation of grant proposals with the PI but is not responsible for generating grant funds. Participate in publications and presentations as author or co‑author. Meet with the PI on a regular basis to discuss research progress and plans. May be asked to write small grant proposals or NRSA/T32 applications. Spend about 75% of time on bench research experimentation and 25% of time on writing articles/analyzing data/online research. Knowledge, Skills, and Abilities Ability to work semi‑independently on research projects within an area of specialization. Thorough technical and theoretical knowledge of the research project and the objectives.Demonstrated aptitude to perform experimental protocols and procedures, including detailed data collection and analysis. Minimum Qualifications Doctorate (PhD, MD or MD/PhD) in immunology or an area directly related to the field of research specialization. Up to 3 years of relevant post‑doctoral experience. Preferred Qualifications Outstanding publication record from prior graduate and/or postgraduate training and/or existing extramural funding. Benefits Outstanding UA benefits include health, dental, vision, and life insurance; paid vacation, sick leave, and holidays; UA/ASU/NAU tuition reduction for the employee and qualified family members; access to UA recreation and cultural activities; and more. #J-18808-Ljbffr
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